^18:22
The music of harpists and musicians, pipers and trumpeters,
will never be heard in you again.
No worker of any trade
will ever be found in you again.
The sound of a millstone
will never be heard in you again.

The music of harpists and musicians, pipers and trumpeters,
will never be heard in you again.

In Ecclesiastics 8:14-15, the wise one, Solomon, claims there isn't much more to life than to eat, drink, and be merry. 'To be merry' usually includes music as this portion of the verse suggests. So when the music stops, we could say that the desire to live has ceased. This is what Isaiah 24:1-8-13 is talking about.

Note that the harp seems to be one of God's favorite instruments. Those who refused to take the mark of the beast are standing in the sea of glass holding the harps of God (Revelation 15:2). Paul says that the 'kingdom of God' is not eating or drinking but rather RIGHTEOUSNESS, PEACE, and JOY in the Holy Spirit (Romans 14:13-17-23). Perhaps these instruments and musicians are symbolic of these spiritual life attributes.

No worker of any trade
will ever be found in you again.

With the global economy totally destroyed and with no obvious market for your crafts, why work to produce goods ANY LONGER? Or this is another way of saying the desire to live is gone.

The sound of a millstone
will never be heard in you again.