16:1And I heard a loud voice from the temple, saying to the seven angels, "Go and pour out the seven bowls of the wrath of God into the earth."

And I heard a loud voice from the TEMPLE,

The voice coming from the TEMPLE indicates this is a direct command from God. John probably recognizes this loud voice as the same one as in Revelation 1:10. That loud voice asked John to start recording the whole revelation we are studying.

saying to the seven ANGELS,

Angels don't do anything on their own. They ALWAYS are obedient (except for Lucifer and his followers). Recall, however, that these angels served in close proximity to God (Revelation 15:6).

"Go and pour out the seven BOWLS of the WRATH OF GOD into the earth."

This command and the subsequent pouring of the bowls fulfills the first part of Zephaniah's prophesy (Zephaniah 3:8-13). It also is the "quickly" part of the third woe (Revelation 11:14).

God is no longer willing to tolerate unrepentant mankind nor the Antichrist (Satan in a human body). Isaiah in Isaiah 42:5-8-9 says that God will not give His glory to another. Yet that is exactly what mankind at this time is doing. LOOK OUT! This is a direct violation of God's commandment (Exodus 20:4-6). A JEALOUS and HOLY GOD will extract vengeance!

A side note: Where these bowls are to be poured is translated in many different ways. That is, "into, upon, on, over" are just a few of the prepositions used to identify where on earth the wrath will hit. Since the earth has never experienced the FULL WRATH OF GOD before (we got a little taste in Noah's time), these seven BOWLS (plagues) will have a GREAT (this word is used in chapter 16 more than any other chapter in the Bible....watch for all the GREATs) impact especially on those who have the mark of the beast.